As Madjack says, depends where you want to go. Lots of good choices.
If you want to stay in that area, go back north to Marietta and ride 26 north, 255 over to the river and then 536 back to 78 and ride 78 west awhile. Really, anything in the triangle between I-70, I-77 and the Ohio River is good.
If you want to go east through W.Va., I usually take 47 east out of the Parkersburg area, then maybe ride 16 south to US 33 east, which is good through Glenville. Got lots a kin from that area. My favorites are US 250 and US 33 over in the Seneca Rocks area. But none of those roads are exactly secrets.
Tell us how much time you've got and where you want to end up and we could give more specific recommendations.