Basic ergonomics: I was considering the KTM Superduke 1290 and this bike (I had deposits down on both of them. I was first on both dealerships' lists), but the info on cycle-ergo.com had me a bit concerned about the KTM, and thinking more positively about the BMW. My old K1200R fit me so well it was as if they'd used my body to design the ergs of the bike, and according to Cycle-ergo.com the new S1000R fit almost exactly the same. The KTM, though, had a far more upright position, which worried me.
When I actually did test ride the KTM, it turns out I was right to be concerned. The bike has an adjustable bar clamp (which is cool) but even with it all the way forward and perhaps swapping out for a straighter bar I'd still be too upright. The S1000R, though, fit me like a glove. I can find no fault with the ergs of the bike, but I'm sure the pegs will be too high for many. In fact, I suspect that more people would find the Superduke comfy than the S1000R, with its lower pegs and more upright bars- but not me.
The saddle is fine, but I'm not particularly particular about those things. I've raced bicycles for most of my life, and compared to those saddles any motorcycle seat is a barcalounger.
Controls: The heated grips are BMW style, with high/low/off settings. Because the bars are completely exposed in the breeze, the grips aren't as effective as they might be on other bikes, even though they do get plenty hot. Some on the S1000R board have fit GS-style handguards, which would help keep the mitts warm. I might do that at some point in the future for cold-weather riding, but hey- I live in Southern California and only get the occasional snowy, icy ride.
The bike has non-BMW traditional turn signals. In fact, all current BMWs have the Japanese-standard style signal switches now. The left switch assembly also has the button to turn the ABS and TC off, and another button to change the preload settings for the DDC (Dynamic Damping Control, or electronic suspension) in addition to the typical high beam switch, turn signals, and trip/info switches. It sounds really busy, but it isn't too bad. On the top of the switch housing is where the magic happens- the cruise control. It functions exactly like a car CC, with an on switch and a separate set/resume switch. It's dead simple to use, and works flawlessly. The CC has some interesting quirks which I'll detail later.
On the right side you have the heated grip switch, the TC/power map switch and the kill switch/starter button. The mode switch is difficult to hit with your thumb while maintaining throttle, so I generally reach across with my left hand. Otherwise it's all easy-peasy.
The shifter is equipped with a quick-shift, which completely rocks. Once you get used to the things you never want a bike without. Same for the slipper clutch. Seriously, I'm not going to buy another bike without them.
The brakes are absolutely freaking awesome. Hand of God type awesome. One finger and your eyeballs launch out of your head awesome. Seriously, they are unbelievable. I'm used to them now, having had the same brakes on my S1000RR, but whenever I jump on another bike I wonder why it is so much work to slow down. The ABS is generally unnoticeable, and its thresholds are set by the TC mode you choose. In "Rain" mode the ABS kicks in a lot earlier, and in "Dynamic Pro" mode the rear has no ABS at all and the front only kicks in very little and very late in the game. The brakes are sometimes linked. In "Rain" or "Road" mode the front lever activates the rear as well (to a degree). In "Dynamic" or "Dynamic Pro" modes the brakes are independent. At no point does the rear lever activate the front brakes.
The gearbox is smooth and the shifts are clean and sure. Maybe not quite Honda perfect, but at least as good as, say, a GSXR gearbox. The engine vibes exist, and are more exaggerated than in a Honda or Kawasaki, but again, no rougher than a GSXR. I had a set of Manic Salamander throttle locks from the S1000RR, and I swapped them onto the new bike even though it has cruise control. The heavy weight of the things helps quell the vibes a bit I'm sure.